Engineering polypeptide folding through trans double bonds: Transformation of miniature β-meanders to hybrid helices

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Abstract

Utilization of conjugated double bonds to engineer the novel folded miniature β-meander type structures, single step transformation of miniature β-meanders into ααγ4-hybrid peptide 10/12-helices using catalytic hydrogenation, their solution and single crystal conformations are reported.

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Ganesh Kumar, M., Benke, S. N., Poopathi Raja, K. M., & Gopi, H. N. (2015). Engineering polypeptide folding through trans double bonds: Transformation of miniature β-meanders to hybrid helices. Chemical Communications, 51(69), 13397–13399. https://doi.org/10.1039/c5cc04523a

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