Management of large periapical lesion using platelet-rich fibrin mixed with bone graft-A case reports

Abstract

Dental trauma is one of the factors which is associated with disruption of blood supply to the pulp which is responsible for the occurrence of pulpal necrosis later developing into endodontic infection. Pulpal infection may be immediate or delayed. In young patients with delayed treatment, the pulp may show various alterations like internal resorption, dystrophic calcification, and pulpitis which may change into partial or total necrosis of pulp. Periapical surgery is required when periradicular pathosis associated with endodontically treated teeth which cannot be resolved by nonsurgical root canal therapy (retreatment), or when retreatment has been unsuccessful, not feasible or contraindicated. Faster the regeneration of bone, better the prognosis. Platelet rich fibrin has many advantages over platelet-rich plasma as it provides a physiologic architecture that is very favorable to the healing process, which is obtained due to the slow polymerization process. Being a rich source of growth factors, platelet rich fibrin (PRF) possess many advantages in bone regeneration. This case reports shows the successful treatment of a trauma induced large periapical lesion using PRF mixed with bone graft.