Prophylactic diazepam in prevention of contrast media‐associated seizures in glioma patients undergoing cerebral computed tomography

Abstract

Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media‐associated seizures from 16% to 2% in a prospective, randomized series of glioma patients. Factors related to increased risk of contrast media‐associated seizures are (1) prior seizure history due to glioma and/or prior contrast media and (2) prior or concurrent brain antineoplastic therapy. Factors not related to an increased risk of contrast media‐associated seizures are (1) contrast media dosage, (2) type or grade of glioma, and (3) computerized tomographic apperance of the glioma. Therories regarding the etiology of contrast media‐associated seizures are discussed. Copyright © 1984 American Cancer Society