Metabolic Polymorphisms and the Micronucleus Frequency in Buccal Epithelium of Adolescents Living in an Urban Environment

Abstract

Micronuclei and other biomarkers were evaluated in oral cells from 11-to 16-year-old girls living in a foster home in the central area of México City. Variables analyzed for possible association with these biomarkers include smoking habits, body mass index, metabolic polymorphisms for NAT1 and GSTM1 and whether the cells were obtained from the cheek or pharynx. The results indicated that individuals having the NAT1 * 10 homozygous genotype showed a significant increase in chromatin buds and binucleated cells. When the damage in the cheek was compared with damage in the pharynx, a significant increase in micronuclei and binucleated cells was found for the latter tissue in all the individuals analyzed. © 2003 Wiley-Liss, Inc.