Bismuth nitrate pentahydrate-induced novel nitration of eugenol

Abstract

Background:Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhancethe medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate hasbeen established as an excellent eco-friendly nitrating agent for several classes of organic compounds.Results:Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twentyfive different conditions have been studied. The microwave-induced solvent-free reaction has been identified asthe best condition.Conclusions:Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized orisomerized product could be detected.