Synthesis and characterisation of phenanthroline adducts of Pb(II) complexes of BisN-alkyl-N-ethyldithiocarbamates

Abstract

Dithiocarbamates are a class of met al-chelating compounds with various applications in medicine. They have been used for the treatment of bacterial and fungal infections, possible treatment of AIDS, and most recently cancer. Dithiocarbamates are well-known compounds to bind strongly and selectively to many met al ions.Dithiocarbamate ligands readily form chelates with met al ions through its two donor sulphur atoms.A new series ofplumbum(II) complexes with mixed ligands, dithiocarbamate, and 1,10-phenanthroline were successfully synthesised using in situ method. Microelemental analysis data of the complexes were in agreement with the general formula, Pb[S 2 CNR'R"] 3 phen (R' = ethyl, R" = butyl, cyclohexyl; phen = 1,10-phenanthroline). Infrared spectra of the complexes showed that the thioureide v(C-N) band was in the region 1450-1500 cm -1. The unsplitting band of v(C-S) in the region 930-1000 cm 1indicated the bidentate nature of the chelated dithiocarbamato ligands. The 13 C NMR chemical shift of the carbon atom of the N-CS2 group appeared in the range of 202-207 ppm.