A two-step synthesis of pyridoxatin analogues

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Abstract

Condensation of 4-hydroxy-2-pyridone (4) with citronellal (10) affords o-quinone methide intermediate 11, which reacts further to give inverse electron Diels-Alder adducts 12 (46%) and 16 (25%) and ene adduct 14 (28%). Oxidation of 12 and 14 by Sammes' procedure affords pyridoxatin analogues 13 (54%) and 15 (48%). © 1994.

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Snider, B. B., & Qing, L. (1994). A two-step synthesis of pyridoxatin analogues. Tetrahedron Letters, 35(4), 531–534. https://doi.org/10.1016/S0040-4039(00)75830-8

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