Formulation and Evaluation of Carbamazepine Cubosomal Transdermal Patch

Abstract

Cubosomes, nanostructured lipid carriers, have attention in pharmaceutical research for their potential in efficient drug delivery systems. This study aimed to formulate optimized Carbamazepine cubosomes using Poloxamer107 as a stabilizing agent and GMO as the lipid component, intending to develop a transdermal patch for enhanced drug delivery. The cubosome formulations were systematically prepared via a bottom-up approach method, optimizing various parameters such as Poloxamer concentration, GMO ratio, and sonication time to achieve the desired characteristics. The dispersions of cubosomes were assessed for properties including zeta potential, particle size, drug loading capacity and polydispersity index. Subsequently, the optimized cubosome formulation was integrated into a transdermal patch matrix and characterized for its in-vitro drug release profile, drug kinetics using established methodologies. The results revealed that the formed cubosomes exhibited excellent stability, high drug loading capacity and uniform particle size distribution. The transdermal patch incorporating the optimized cubosome formulation demonstrated sustained drug release kinetics over an extended period. Short stability studies were performed on optimized formulation.