Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: A scoping review

Abstract

Background: Radiotherapy is one of the main treatments for head and neck cancer; however, due to its non-selectivity the glandular tissue can be affected. This scoping review aimed to identify the evidence about mesenchymal stem cell therapies for irradiated salivary gland regeneration. Material and Methods: Two independent reviewers performed a literature search in MEDLINE/PubMed, Scopus, and Web of Science. The inclusion criteria were: 1) studies evaluation regeneration of irradiated salivary glands by stem cell therapies (cell-based or cell-free), (2) in vivo studies. Results: The search resulted in 13 included studies. In general, both therapies demonstrated increased salivary levels, with mucin and amylase increased and structural protection of acinar cells. The cell-free therapy based on labial glands stem cell extract demonstrated a higher number of parasympathetic nerves. Conclusions: Stem cell therapies (cell-free and cell-based) appear promising strategies for recovering saliva production in patients presenting irradiation-induced hyposalivation, with positive results toward regeneration of the form and function of the glands. However, due to the scarcity and heterogenicity of these pre-clinical studies, it is not possible to indicate which is the more indicated therapy.