Effects of Ringer's lactate or Ringerfundin resuscitation on the acid–base status and serum electrolytes in septic oncologic patients

Abstract

A randomized controlled study of fluid resuscitation in a clinical oncologic ICU. The aim of this study was to determine the effects of resuscitation on patients� electrolyte concentrations and acid�base status. Forty patients in the first hours after diagnosis of septic shock (early hours) were randomized to receive solutions of either Ringer�s lactate (n = 20) or Ringerfundin (n = 20) for fluid resuscitation. The amount of fluid needed to reach the goals of therapy was compared between groups. Also, bicarbonate, base excess, pH, chloride, sodium, potassium, calcium, magnesium, albumin, anion gap, SIDe, SIG and lactate were compared at baseline, 2 hours after initial therapy, 6 hours after and 24 hours after.