Effect of Correction of Metabolic Acidosis on Serum Interleukin 10 Levels in Chronic Hemodialysis Patients

Abstract

Background: Metabolic acidosis is a common complication in chronic hemodialysis (HD) patients and can cause loss of lean body mass. Interleukin 10 (IL-10) also is increased in chronic HD patients and has a prognostic value. Objectives: The aim of this study was to evaluate the effect of correction of metabolic acidosis on serum IL-10 levels in chronic hemodialysis patients. Patients and Methods: Forty chronic hemodialysis patients with predialysis bicarbonate levels <22 mEq/l were treated by increasing dialysate bicarbonate concentration till achieving serum bicarbonate ≥ 22 mEq/l. Serum IL-10 levels were measured at baseline and one month after correction of metabolic acidosis. Results: Bicarbonate levels significantly increased at end of study (22.83±0.71 vs 18.85±1.12 mEq/l, p<0.001). Serum IL-10 levels significantly decreased after correction of metabolic acidosis (19.91±6.68 vs 25.89±10.64 pg/ml, p<0.001) and the change of IL-10 was significantly correlated with the change in bicarbonate (r =-0.436, p = 0.005). Conclusions: Correction of metabolic acidosis in chronic hemodialysis patients was associated with decrease in serum IL-10.