Inhibitory effect of arphamenine a on intestinal dipeptide transport

Abstract

Arphamenine A, an Arg-Phe analog without a peptide bond, has been reported to be a possible inhibitor of the peptide transporter [H. Daniel and S. A. Adibi, FASEB J., 8, 753 (1994)]. The present study demonstrates that arphamenine A is not a real inhibitor, but is a substrate for the transporter, being transported transepithelially under a proton gradient. The substrate specificity of the peptide transporter was wider than expected. © 1996, Taylor & Francis Group, LLC. All rights reserved.