Recovery of leukæmogenic agent from non-leukæmic tissues of thymectomized mice

Abstract

IT has been shown by Gross and others1 that filtrates of leukæmic tissues are leukæmogenic following injection into new-born mice of a low-leukæmic strain, and that total thymectomy prevents the development of lymphocytic leukæmia in inoculated mice2. On the other hand, normal thymuses grafted to inoculated thymectomized hosts as late as 6 months after thymectomy develop lymphocytic neoplasms3. It follows, therefore, that a leukæmogenic agent might be recoverable from the tissues of inoculated mice up to 6 months or more after thymectomy. © 1960 Nature Publishing Group.