Transition metal-catalyzed synthesis of spirooxindoles

Abstract

Spirooxindole is a principal bioactive agent and is observed in several natural products including alkaloids. They are broadly studied in the pharmaceutical field and have a significant role in the evolution of drugs such as anti-viral, anti-cancer, anti-microbialetc.In organic chemistry, an indispensable role is presented by transition metal catalysts. An effective synthetic perspective to spirooxindoles is the use of transition metals as the catalyst. This review discusses the synthesis of spirooxindoles catalyzed by transition metals and covers literature up to 2020.