Cd2+ Triggered the FRET "ON": A New Molecular Switch for the Ratiometric Detection of Cd2+ with Live-Cell Imaging and Bound X-ray Structure

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Abstract

On the basis of the Förster resonance energy transfer mechanism between rhodamine and quinoline-benzothiazole conjugated dyad, a new colorimetric as well as fluorescence ratiometric probe was synthesized for the selective detection of Cd2+. The complex formation of the probe with Cd2+ was confirmed through Cd2+-bound single-crystal structure. Capability of the probe as imaging agent to detect the cellular uptake of Cd2+ was demonstrated here using living RAW cells.

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Aich, K., Goswami, S., Das, S., Mukhopadhyay, C. D., Quah, C. K., & Fun, H. K. (2015). Cd2+ Triggered the FRET “ON”: A New Molecular Switch for the Ratiometric Detection of Cd2+ with Live-Cell Imaging and Bound X-ray Structure. Inorganic Chemistry, 54(15), 7309–7315. https://doi.org/10.1021/acs.inorgchem.5b00784

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