Synthesis and evaluation of antimicrobial activities of new piperidine derivatives

Abstract

Nitrogen heterocycles with piperidine rings are the most prominent structural features and frequently utilized by pharmaceuticals. In this study, we have disclosed the synthesis of new compounds with piperidine motif. The synthesis of these derivatives was achieved using Wittig olefination, O-alkylation, and nucleophilic substitution reaction. The antimicrobial activity was performed by disc diffusion method utilizing Staphylococcus aureus as gram-positive and Escherichia coli as a gram-negative bacterial pathogen, respectively.