Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines

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Abstract

The cisplatin prodrug c,c,t-[Pt(NH 3) 2 Cl 2 (O 2 CCH 2 CH 2 CO 2) 2 ] 2- (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, also achieved using PEI-coated AuNPs.

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Garaikoetxea Arguinzoniz, A., Gómez Blanco, N., Ansorena Legarra, P., & Mareque-Rivas, J. C. (2015). Enhanced cancer cell killing of a Pt(iv) prodrug promoted by outer-sphere coordination with polyethyleneimines. Dalton Transactions, 44(16), 7135–7138. https://doi.org/10.1039/c5dt00175g

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