Abstract
Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine. © 2013 John Wiley & Sons A/S.
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Panda, S. S., Ibrahim, M. A., Küçükbay, H., Meyers, M. J., Sverdrup, F. M., El-Feky, S. A., & Katritzky, A. R. (2013). Synthesis and antimalarial bioassay of quinine - peptide conjugates. Chemical Biology and Drug Design, 82(4), 361–366. https://doi.org/10.1111/cbdd.12134
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