Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin e

Abstract

Background: Immunoglobulin E (IgE) plays a central role in allergic disease. The B-cell receptor CD23 is pivotal in regulating IgE synthesis. Results: Ca2+-dependent structural changes in CD23 enable additional interactions with IgE. Conclusion: Mechanism for Ca2+-induced increase in affinity is revealed. Significance: Ca2+ binding brings an extra degree of modulation to CD23 function. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.