Impact of timely antibiotic administration on outcomes in patients with severe sepsis and septic shock in the emergency department

Abstract

What is already known Timely antibiotic administration is a particularly crucial element for survival in patients with severe sepsis and septic shock. What is new in the current study Timely administration of antibiotics was also associated with better reversal of organ failure and reduction of hospital length of stay. Objective We aimed to investigate the effect of timely antibiotic administration on outcomes in patients with severe sepsis and septic shock. Methods We analyzed data from a sepsis registry that included adult patients who initially presented to the emergency department (ED) and met criteria for severe sepsis or septic shock. Timely antibiotic use was defined as administration of a broad-spectrum antibiotic within three hours from the time of ED arrival. Multivariable logistic and linear regression analyses were performed to assess associations between timely administration of antibiotics and outcomes, including hospital mortality, 48-hour change in Sequential Organ Failure Assessment (SOFA) score (delta SOFA), and hospital length of stay (LOS). Results A total of 591 patients were included in the study. In-hospital mortality was 16.9% for patients receiving timely antibiotics (n = 377) and 22.9% for patients receiving delayed antibiotics (n = 214; P = 0.04). The adjusted odds ratio for in-hospital survival was 0.54 (95% confidence interval [CI], 0.34 to 0.87; P = 0.01) in patients who received timely antibiotics. Timely antibiotic administration was also significantly associated with higher delta SOFA (2 vs. 1) and shorter hospital LOS among survivors (11 days vs. 15 days). Multivariable linear regression analyses showed that timely antibiotic administration was significantly associated with increased delta SOFA and decreased hospital LOS. Conclusion Antibiotic administration within three hours from the time of ED arrival was significantly associated with improved outcomes, including in-hospital survival, reversal of organ failure , and shorter hospital LOS, in patients with severe sepsis and septic shock.