Dysregulated MicroRNA expression and chronic lung allograft rejection in recipients with antibodies to donor HLA

Abstract

The pathogenesis of chronic rejection, Bronchiolitis Obliterans Syndrome (BOS) following lung transplantation (LT) is poorly understood. We hypothesized that development of antibodies to HLA (DSA) is associated with dysregulation of microRNA (miRNA) that predisposes BOS. Towards this, miRNA profiling of mononuclear cells from 10 stable LT (DSA-BOS-), 10 LT with DSA+BOS- (DSA group) and 10 LT with DSA+BOS+ (BOS group) were performed. Prediction by mirPath indicated that differential miRNAs in DSA+BOS- compared to stable are significantly up-regulated (relative fold >2, p- 2, p-