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Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo

Molecular Cell (2019) 75(1) 154-171.e5
DOI: 10.1016/j.molcel.2019.04.014
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Abstract

Jung et al. show that sperm and oocyte promoters and enhancers contain ATAC-seq accessible sites suggesting the presence of Pol II, Foxa1, ERα, and AR. Accessibility in gametes persists in early embryos. Interactions mediated by CTCF in gametes are inherited from each parent and become the same in 8-cell embryos.

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Jung, Y. H., Kremsky, I., Gold, H. B., Rowley, M. J., Punyawai, K., Buonanotte, A., … Corces, V. G. (2019). Maintenance of CTCF- and Transcription Factor-Mediated Interactions from the Gametes to the Early Mouse Embryo. Molecular Cell, 75(1), 154-171.e5. https://doi.org/10.1016/j.molcel.2019.04.014

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