Chromone studies. Part 11. Synthesis and electron-impact mass spectrometric study of granulosin and side-chain analogues

Abstract

Granulosin, a chromone constituent of the bark of Galipea granulosa, and four analogues, all of which exhibit toxicity to the brine shrimp Artemia salina, have been prepared from 2′,3′,4′-trihydroxyacetophenone. High-resolution mass spectrometric analysis has permitted elucidation of the fragmentation patterns exhibited by these systems following electron-impact ionisation.