Efficacy of nitroscanate in the treatment of helminth infections in dogs: comparative evaluation with mebendazole formulations.

Abstract

Nitroscanate (50 mg/kg) was compared with three different commercial mebendazole preparations in 92 puppies from 13 litters infected with Toxocara canis and Ancylostoma caninum, and in 84 dogs with mixed nematode and Dipylidium caninum infections. Faecal egg counts showed that, 10 days after treatment, T. canis was eliminated from 31 of 33 puppies and both of two dogs given nitroscanate and from 20 of 33 puppies and all of five dogs given mebendazole, while A. caninum was eliminated from all of three puppies and four dogs given nitroscanate and two of three puppies and eight of 12 dogs given mebendazole. Both drugs eliminated all Toxascaris leonina and Uncinaria stenocephala infections, but not Trichuris vulpis infections. Dosing with arecoline hydrobromide on day 11 revealed 99% efficacy of nitroscanate against D. caninum, compared with 95% for mebendazole.