Nose-to-Brain Translocation and Cerebral Biodegradation of Thin Graphene Oxide Nanosheets

Abstract

Depending on their applications, graphene-based materials may be inhaled. After exposing mice via the nasal cavity, Newman et al. demonstrate that thin graphene oxide sheets can infiltrate several brain regions in a size-dependent fashion. They show that the materials gradually experience changes consistent with biodegradation in the brain.