Effects of salt intervention on serum levels of Klotho influenced by salt sensitivity

Abstract

Klotho was involved in sodium reabsorption and the regulation of blood pressure. Animal studies indicated Klotho deficiency could mediate the development of salt-sensitive hypertension, indicating its correlation with salt sensitivity. We aimed to explore the responses of Klotho to salt intake through dietary intervention in Chinese adults. Forty-four participants were enrolled from Lantian county of Shaanxi, China. All participants sequentially underwent a 3-day normal diet, a 7-day low-Na+ diet, and a 7-day high-Na+ diet. The concentrations of serum Klotho were assessed by using ELISA kits. Serum level of Klotho was 360.44 ± 93.89 pg/mL at baseline and increased while changed to low-salt diet (478.65 ± 183.25 vs 360.44 ± 93.89 pg/mL, P