Cholesterol and Triglycerides Metabolism Disorder in Malignant Hemopathies

Abstract

The aim of this chapter is to achieve a synthesis of the major studies existing in the literature on correlations between lipid metabolism and malignant hemopathies. We will expose the fundamental research data and their impact on clinical treatment. The purpose of this review is to help the clinicians to understand better the pathological disorders of the lipid metabolism and use the existing therapeutic arsenal to improve the treatment outcomes. The research and the recognition of the presence of dyslipidemia is useful, as well as monitoring them during oncological therapy. The treatment of dyslipidemia may not be only an option when a patient with malignant hemopathy has acquired multidrug resistance. It can contribute to reversing this resistance, but it can also have adverse effects that must be recognized, followed and treated. There are numerous studies in literature, but the connection between blood levels of various lipid fractions and hematologic malignancies is still unknown (Cvetkovic et al., 2009). Various epidemiological studies have found that between blood lipids and various neoplastic diseases there are correlations, thus the question is whether in the pathogenesis of cancer are not involved various lipid disorders (Moschovi M et al., 2004). At the same time it is believed that in patients with metabolic syndrome (MS), blood lipid levels may have correlations with the risk of cancer (Ulmer H et al., 2009).