Influence of an α -amylase inhibitor (BAY d 7791) on blood glucose, serum insulin and nefa in starch loading tests in rats, dogs and man

Abstract

An a-amylase inhibitor isolated from wheat was used in experiments involving rats, dogs and healthy volunteers. The hyperglycaemia and hyperinsulinaemia resulting from starch loading could be reduced dose dependently by the inhibitor. Its inhibitory effect is specific and limited to α-amylase. In loading tests with cooked starch the effect on blood sugar is markedly diminished. © 1973 Springer-Verlag.