Effect of oral administration of gelatin and collagen peptides on the hydroxyproline content of rats skin

Abstract

The effect of gelatin and collagen peptides (each 50 and 100 mg oral administration for 21 days) on the skin collagen synthesis, which used the index of hydroxyproline content in the soluble fraction of skin, was studied by male Wistar rats. In the case of unshaved or shaved treatment, the hydroxyproline contents in 50 and 100 mg gelatin groups did not increase compared with control group. In contrast, the hydroxyproline contents in 50 and 100 mg collagen peptides groups resulted in a significant increase compared with control group. These results suggest that the administration of collagen peptides enhance the hydroxyproline content in the soluble fraction of skin, which may be related to skin collagen synthesis of rats, more easily than gelatin.