Genotyping paraoxonase polymorphisms in iranian farmers exposed to organophosphate pesticides

Abstract

Paraoxonase 1 is an esterase that associates with other enzymes to detoxify organophosphate pesticides. The expression and activity of paraoxonase is due to polymorphisms of the paraoxonase gene. Thus, the present study aimed to determine the activity of paraoxonase and paraoxonase genotypes along with their relationships, the risks and medical conditions in Iranian workers that were occupationally exposed to organophosphates. Workers (n = 80) exposed to organophosphates and controls (n = 160) that were not exposed to Organophosphates gave a blood sample in order to have two polymorphisms of paraoxonase, paraoxonase activity buth)'IYlcholinesterase activity and their interactions investigated. The results showed that the exposed group had significantly (p<0.05) less paraoxomse activity than the controls (90.04±4.632 and 149.8±5.236 nmol min-' mL, respectively). The Q/Q, QIR and RIR genotypes (highest to lowest rates, respectively) significantly hydrolyzed paraoxon (i.e., paraoxomse activity) in both groups (p