Extracellular proteasomes

Abstract

Little-known to a wide range of specialists details of the functioning of one of the main participants in cellular metabolism – a complex of neutral proteases with their regulators, which is called “proteasome” – are observed in this paper. The review analyzes the works of recent years devoted to the study of the participation of proteasomes in intercellular signaling and catabolism of regulatory and signaling proteins in the extracellular space.