Synthesis and properties of poly(methacrylate) bearing a phosphorylcholine analogous group

Abstract

A novel type of methacrylate bearing a phosphorylcholine analogous group, 2-[3′-(trimethylammonium)propylphosphoryl]ethyl methacrylate (TPM) was synthesized. TPM was polymerized and copolymerized with vinyl monomers in the presence of radical initiators. Monomer reactivity ratios and Q and e for TPM were determined. A critical micelle concentration (CMC) of TPM was 3.6 ×10-3 mol l-1. Two types of copolymer microspheres of methyl methacrylate (MMA) with TPM or 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared from emulsifier-free emulsion copolymerizations over the CMC. The suppression of bovine serum albumin (BSA) adsorption onto poly(TPM-co-MMA) microsphere was similar to that onto the poly(MPC-co-MMA). The length of three methylene units between zwitter-ions in the phosphorylcholine group could not prevent depressing BSA adsorption.