A novel function of the fe65 neuronal adaptor in estrogen receptor action in breast cancer cells

Abstract

Background: Fe65 is a neuronal adaptor with essential roles in neuronal cells. Results: Fe65 regulates promoter recruitments of the estrogen receptor γ and growth response of breast cancers to estrogens and tamoxifen. Conclusion: Fe65 is a positive regulator of estrogen actions in breast cancer cells. Significance: The studies define a novel role for a neuronal adaptor in estrogen actions in breast cancer cells. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.