Synthesis, characterization and biological properties of Vanadyl(IV) complexes of Diclofenac and Indomethacin: An experimental and theoretical study

Abstract

Two new vanadyl(IV) complexes with the non-steroidal antiinflammatory drugs Indomethacin and Diclofenac were synthesized and characterized by elemental analysis, electronic, diffuse reflectance and FTIR spectroscopies and thermal behavior. The structures of the oxo-vanadium(IV) complexes were obtained by carrying out ab initio calculations (B3LY/3-21G**) owing to the difficulties of obtaining single crystals of good quality for X-ray studies. Indomethacin and Diclofenac did not cause any effect when tested on cellular proliferation in two osteoblast-cell lines in culture (MC3T3E1 and UMR106). The biological effect of the complexes depends on the cellular type and on the nature of the coordinated ligands. Copyright © 2005 John Wiley & Sons, Ltd.