A fluorescent surrogate of thymidine in duplex DNA

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Abstract

DMAT is a new fluorescent thymidine mimic composed of 2′-deoxyuridine fused to dimethylaniline. DMAT exhibits the same pKa and base pairing characteristics as native thymidine residues, and its fluorescence properties are highly sensitive to nucleobase ionization, base pairing and metal binding.

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Mata, G., Schmidt, O. P., & Luedtke, N. W. (2016). A fluorescent surrogate of thymidine in duplex DNA. Chemical Communications, 52(25), 4718–4721. https://doi.org/10.1039/c5cc09552b

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