A large scale huntingtin protein interaction network implicates RHO GTPase signaling pathways in huntington disease

Abstract

Background: Huntington disease is a fatal neuropsychiatric disorder caused by aberrant protein folding and interactions. Results: An interaction network composed of primary and secondary huntingtin-interacting proteins is significantly enriched for pathways implicated in HD, including RhoGTPases. Conclusion: Huntingtin interacts with members of the Rho GTPase signaling pathways and regulates filipodial dynamics. Significance: This protein interaction network provides a resource for HD target discovery. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.