Abstract
A series of new 4-aryl-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)- diones have been synthesized via three component reaction of 1,3-dimethylbarbituric acid with arylglyoxals in the presence of hydrazinium dihydrochloride in ethanol. All of these derivatives may act as potential monoamine oxidase inhibitors.
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Khalafy, J., Rimaz, M., Panahi, L., & Rabiei, H. (2011). A regiospecific One-Pot, Three component synthesis of 4-Aryl-6,8- dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-diones as New potential monoamine oxidase inhibitors. Bulletin of the Korean Chemical Society, 32(7), 2428–2432. https://doi.org/10.5012/bkcs.2011.32.7.2428
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