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Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures

Nature Communications (2024) 15(1)
DOI: 10.1038/s41467-024-46898-1
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Abstract

Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

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Hu, J., Xia, W., Zeng, S., Lim, Y. J., Tao, Y., Sun, Y., … Li, Y. M. (2024). Phosphorylation and O-GlcNAcylation at the same α-synuclein site generate distinct fibril structures. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-46898-1

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