Use of a water-soluble form of cannabinol for the treatment of sleeplessness

Abstract

Abbreviations: L7H, less than 7hours sleep/night; DIS, difficulty initiating sleep; DMS, difficulty maintaining sleep; EMA, early morning awakening; NRS, nonrestorative sleep; CBN, cannabinol Introduction Sleeplessness, defined as less than seven hours sleep at least two nights a week, affects almost everyone at some point. However, it is a chronic condition for up to 36% of the US population. It takes a staggering toll on the economy and personal health, accounting for $63.2 billion of lost productivity annually in the US alone 1,2 and increasing the frequency, severity, and medical costs of personal injury. 3,4 In addition, insufficient sleep duration is associated with serious medical conditions, including obesity, hypertension, hyperlipidemia, inflammation, heart attack, stroke, and diabetes; it results in a 12% increase in mortality. 5-7 Sleeplessness can be classified into four distinct categories. 8