Effect of aspirin on reproductive functions in male Albino rats

Abstract

Aspirin is an organic acid (Acetyl chloride and sodium salicylate used anciently as an anti-clotting agent that reduces the risk of clotting diseases but there is a dearth of information on its effects on androgenic studies histology of the testes, kidneys and livers and reproductions. This study was designed to investigate the effects of aspirin on reproductive parameters and histopathological changes in male Albino rats. Aqueous diluted aspirin was administered orally for 30 days for androgenic and reproductive studies at the dose of 10 mg mL-1 BW. Distilled water (0.05 mL) served as control. Testosterone level was assayed using ELISA, semen analysis were done microscopically. Histology of the testis, kidney and liver was done. Data were analysed using students t-test at p<0.05. Treatment with aspirin 10 mg mL-1 BW caused no significant (p>0.05) increases in body weights of treated rats, relative to control. Aspirin 10 mg mL-1 BW caused significant decrease in testosterone levels and sperm count. Aspirin caused no significant changes in sperm viability but significant increase in abnormal sperm morphology. It caused no visible lesion in the germinal epithelium. © Medwell Journals, 2013.