Sensbio: an online server for biosensor design

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Abstract

Allosteric transcription factor (aTF) based biosensors can be used to engineer genetic circuits for a wide range of applications. The literature and online databases contain hundreds of experimentally validated molecule-TF pairs; however, the knowledge is scattered and often incomplete. Additionally, compared to the number of compounds that can be produced in living systems, those with known associated TF-compound interactions are low. For these reasons, new tools that help researchers find new possible TF-ligand pairs are called for. In this work, we present Sensbio, a computational tool that through similarity comparison against a TF-ligand reference database, is able to identify putative transcription factors that can be activated by a given input molecule. In addition to the collection of algorithms, an online application has also been developed, together with a predictive model created to find new possible matches based on machine learning.

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Tellechea-Luzardo, J., Martín Lázaro, H., Moreno López, R., & Carbonell, P. (2023). Sensbio: an online server for biosensor design. BMC Bioinformatics, 24(1). https://doi.org/10.1186/s12859-023-05201-7

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