Role of hyaluronic acid in post-extraction healing

Abstract

In dental practice, rapid healing of post-extraction wounds is integral in reducing the risk of infection that causes patient discomfort. Wound healing is a dynamic process requiring adequate vascularization and collagen matrix deposition. The renewal of vessels determines traction that stimulates remodelling of the extracellular matrix, potentiating neo-vessel responses. The presence of topical agents may aid the regenerative and repair mechanisms & improve the healing process of damaged tissues. Commercial preparations based on low molecular weight hyaluronic acid (HA) have shown to improve the healing of connective tissue, epithelium, and mucosa. HA is used during the healing process as it primarily creates a temporary structure for depositing extracellular matrix (ECM) proteins, initiates cell adhesion, proliferation, and migration, and regulates vascular endothelial cell function. The present review article discusses the possible complications of delayed post-extraction healing and the role of hyaluronic acid in post-extraction wound healing and alveolar osteitis.