Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration

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Abstract

Objective: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. Method: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. Results: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. Conclusion: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug.

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Fraga, D. B., Réus, G. Z., Abelaira, H. M., De Luca, R. D., Canever, L., Pfaffenseller, B., … Zugno, A. I. (2013). Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration. Revista Brasileira de Psiquiatria, 35(3), 262–266. https://doi.org/10.1590/1516-4446-2012-0858

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