Objective: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. Method: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. Results: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. Conclusion: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug.
Fraga, D. B., Réus, G. Z., Abelaira, H. M., De Luca, R. D., Canever, L., Pfaffenseller, B., … Zugno, A. I. (2013). Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration. Revista Brasileira de Psiquiatria, 35(3), 262–266. https://doi.org/10.1590/1516-4446-2012-0858