Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

Bruce A. Cook; John R. Sinnhuber; Paul J. Thomas; Thomas A. Olson; Toby A. Silverman; Robert Jones; V. Michael Whitehead; Frederick B. Ruymann

Journal ArticleOPEN ACCESS

Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

Cancer (1983) 52(1) 61-63

DOI: 10.1002/1097-0142(19830701)52:1<61::AID-CNCR2820520112>3.0.CO;2-W

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Abstract

Indicine N‐oxide, a pyrrolizidine alkaloid, was given to a five‐year‐old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N‐oxide toxicity. Cancer 52:61‐63, 1983. Copyright © 1983 American Cancer Society

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Cook, B. A., Sinnhuber, J. R., Thomas, P. J., Olson, T. A., Silverman, T. A., Jones, R., … Ruymann, F. B. (1983). Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study. Cancer, 52(1), 61–63. https://doi.org/10.1002/1097-0142(19830701)52:1<61::AID-CNCR2820520112>3.0.CO;2-W

Hepatic failure secondary to indicine n‐oxide toxicity. A pediatric oncology group study

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