Tissue Engineering of Bone: Critical Evaluation of Scaffold Selection

Abstract

"Bone is a specialized connective tissue, most prominently characterized by its mineralized organic matrix that imparts the physical properties that allow bone tissue to resist load, to support functional organs, and to protect highly sensitive body parts. Bone loss and bone damage may occur as a result of genetic conditions, infectious diseases, tumours, and trauma. Bone healing and repair, involves integrative activity of native tissues and living cells, and lends itself to the incorporation of naturally derived or biocompatible synthetic scaffolds, aimed at replacing missing or damaged osseous tissues. There are several modalities of bone regeneration including tissue engineering, guided bone regeneration, distraction ontogenesis, and bone grafting. This book concentrates on such procedures that may well be counted among the recent outstanding breakthroughs in bone regenerative therapy.". Introductory chapter -- Stem cell based bone tissue engineering -- Autologous cell therapies for bone tissue regeneration -- Signals between cells and matrix mediate bone regeneration -- Tissue engineering of bone: critical evaluation of scaffold selection -- Tissue engineering in maxillar sinus lifting: a comparation of different grafts and confocal laser scanning microscopic evaluation -- Bioresorbable collagen membranes for guided bone regeneration -- Augmentation and preservation of the alveolar process and alveolar ridge of bone -- Distraction osteogenesis and its challenges in bone regeneration -- Skull expansion by spring-mediated bone regeneration -- The use of cancellous bone-block allograft for reconstruction of the atrophic alveolar ridge -- Self-regenerative ability of bone and micro processing of bone-component material in orthopedic surgery healing -- Microstructure and biocompatibility of hydroxyapatite porous ceramics designed by a partial dissolution-precipitation technique with supersonic treatment for bone regeneration -- Development and evaluation of superporous ceramics bone tissue scaffold materials with triple pore structure a) Hydroxyapatite, b) beta-tricalcium phosphate -- Histocompatibility of acellular matrix bone with osteoblast and vascular endothelial cells.