One-pot tandem palladium-catalyzed decarboxylative cross-coupling and C-H activation route to thienoisoquinolines

Abstract

Two experimental approaches to the synthesis of a scarcely reported biologically active thienoisoquinoline system are demonstrated. A 5-step linear synthesis employing a palladium-catalyzed decarboxylative cross-coupling and functionalization sequence allowed for the preparation of a diverse range of substituted thienoisoquinoline systems. Alternatively the palladium-catalyzed decarboxylative cross-coupling and C-H activation steps can be telescoped to produce a one-pot reaction sequence that provides efficient access to aryl-substituted thienoisoquinolines. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.