Interpersonal differences caused by adaptogen changes in the entropies of eeg, hrv, immunocytogram, and leukocytogram

Abstract

Background. Previously, we have shown that in patients the entropy of HRV and spectral power density (SPD) of loci of EEG as well as of Immunocytogram (ICG) and Leukocytogram (LCG) is characterized by a large variation. The method of cluster analysis is revealed that in members of the major cluster (60%), the entropy of EEG, HRV, ICG and LCG varies within the normal range (-0,5σ ÷ +0,5σ). The members of the next largest cluster (23%) are characterized by a moderately increased entropy of the SPD of EEG in combination with the normal entropy of the ICG and the moderately reduced entropy of HRV and LCG. The members of the third cluster (9%) noted a significantly lower entropy (negentropy) of the SPD in loci F3, F4, T3 and C4; in addition, there is a moderate decrease in the entropy of the LCG. Instead, members of the last cluster (8%) noted the negentropy of SPD in paired loci Fp1 and Fp2, T5 and T6, T3 and T4, F7 and F8 as well as O1 and O2; in addition, there is a moderate decrease in entropy of the ICG. The entropy of other EEG locus as well as of HRV and LCG is within the normal range. The purpose of this study is to analyze variants of changes in entropy under the influence of natural adaptogens and to determine the possibility of their prediction. Material and methods. In basal conditions in 37 men and 14 women with chronic pyelonephritis and cholecystit is in remission as well as without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, we recordedtwice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood we determined relative content of components (RCC) of Immunocytogram (ICG) (T helper, T cytolytic, B and NK lymphocytes) and Leukocytogram (LCG) (Eosinophils, Stub and Segmentonucleary Neutrophils, Lymphocytes and Monocytes). Than we calculated for each locus of EEG and HRV as well as for ICG and LCG the Entropy (H) of normalized SPD or RCC using Shannon’s formula. Results.Three groups of persons were created, significantly different from each other in terms of entropy changes, while the differences between the members of each group were much smaller. Balneotherapy has a generalized negentropic effect on EEG of 66,7% patients (members of first cluster). On the other hand, the members of the other two clusters have substantially increased EEG entropy overall, but there are significant differences with respect to individual loci. The entropy changes of HRV, ICG, and LCG are within ±0,5 σ, which we consider to be insignificant. According to the results of the discriminant analysis, changes in entropy only 11 loci EEG and ICG were identified as characteristic of the clusters. It is shown that both the decrease in entropy in the first cluster and its increase in the third cluster (13,7% of patients) is normalizing. Instead, in the second cluster (19,6%), like the first cluster, only 4 EEG parameters change, whereas the entropy of most parameters rises above the upper limit of the norm, ie the true proentropic effect of balneotherapy takes place. The entropy change directionality is driven by 19 predictors, primarily the initial entropy levels of EEG, HRV, ICG, and LCG, as well as Popovych’s Adaptation and Strain Index and gender, but not the age of the patients. Conclusion. Differentially directed entropy changes under the influence of natural adaptogens are, as a rule, normalizing in nature and predetermined by both its initial levels and other predictors.