P653Reduction of dysfunctional HDL and triglycerides through aerobic training: a randomised, placebo-controlled trial

Abstract

Exercise training increases the high‐density lipoprotein (HDL) cholesterol and is associated with a reduction of the cardiovascular mortality. However, a large por‐ tion of cardiovascular events occur in patients with normal HDL levels. The aim of the present study was to analyze the effects of different exercise modalities on dysfunctional HDL. 75 hypertensive patients were prospectively randomized in three groups to undergo following training modalities for 12 weeks: A. handgrip isometric training 5 times weekly consisting of 2 contractions of 2 min at 30% of maximal power with each arm; B. placebo‐handgrip training 5 times weekly consisting of 2 contractions of 2 min at 5% of maximal power with each arm and C. aerobic exercise training of 30 minutes at least 3 times per week. Blood samples were collected at baseline and after 12 weeks of training in 62 patients. Using a novel assay on the basis of the HDL‐mediated rate of oxidation of dihydrorhodamine (DOR), we determined the functional (redox) properties of HDL. The DOR of each sample was normalized as a ratio of the DOR of a control HDL isolated from pooled serum from all study subjects. Aerobic and isometric exercise led to a significant reduction of the triglycerides (p=0.03 each). Aerobic exercise led to significant reduction of the DOR adjusted for the HDL concentration from 0.99±0.27 0.90±0.29 (no units, p=0.03). The haptoglobin bound HDL, as another marker of dysfunctional HDL, did not change in any group after the training period. All results are presented in Table 1. We correlated further the DOR to known parameters of cardiovascular diseases and to blood pressure finding a significant positive correlation (Figure 1). (Figure Presented).