COMPUTATIONAL EXAMINATION OF FLAVONOID COMPOUNDS: UTILIZATION OF MOLECULAR SIMULATION TO DISCOVER DRUG CANDIDATES FOR COVID-19

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the novel coronavirus disease 19 (COVID19) pandemic. Despite drugs had been deployed through intense research, none has been proven to cure the infection. Flavonoids, a natural substance, have been reported to exhibit various pharmaceutical and medical properties. The aim of this research is to discover lead compounds for covid-19 from flavonoid compounds through in silico study. Through computational examination, the potential of flavonoid compounds against SARS-CoV-2 has been examined and it shows that some flavonoids have potential against SARS-CoV-2.