Adaptive servo-ventilation and central apnea associated with systolic heart failure

Abstract

In individuals with symptomatic congestive heart failure (left ventricular ejection fraction ≤ 45%) and predominately central sleep apnea, does treatment of the sleep apnea with adaptive servo-ventilation (ASV), in addition to guideline based medical treatment change time to first event (composite of first event of death from any cause, lifesaving cardiovascular intervention [cardiac transplantation, implantation of a ventricular assist device, resuscitation after sudden cardiac arrest, or appropriate lifesaving shock], or unplanned hospitalization for worsening heart failure)?